MARK McGuigan and Kyle Turner's goals helped Stranraer move one step closer to safety.
The Blues, who were below par last weekend against Albion Rovers, bounced back in impressive fashion against third placed Airdrie.
Ryan Thomson and Steven Bell were both unavailable while David Wilson and Michael Donald dropped to the bench.
Stranraer boss Stevie Farrell sprang a surprise with Scott Robertson, Kyle Turner, Willie Gibson and Mark McGuigan coming into the team but perhaps not in the positions many expected them.
Craig Pettigrew kept his place at right back, with Robertson slotting in beside Morgyn Neill in the heart of defence and Liam Dick in his usual slot at left back.
The sitting midfield two - usually Bell and Thomson - were replaced by David Barron and top goalscorer and usual striker Craig Malcolm. Kyle Turner started wide on the left, with Scott Agnew on the right and Gibson supporting McGuigan.
It was a bold move but one which paid dividends with the Blues getting in front after just 12 minutes.
Airdrie goalkeeper Rohan Ferguson made a mess of Pettigrew's cross and McGuigan did well to find enough space to turn and fire the ball home through a crowd of players.
Stranraer were well on top during the first half but Airdrie could have levelled after an impressive run from Andy Ryan.
The striker has been a real thorn in Stranraer's side this year and rolled the ball to the unmarked Ryan Conroy, only for the hosts to snuff out the chance.
The Blues had been well on top in the opening 45 minutes and carried that on after the break.
Turner, another who has had to be patient for his chance, capitalised on a slack Ferguson clearance.
The teenage midfielder still had plenty to do but strode forward with purpose and coolly slotted the ball beyond the Airdrie number one.
Mark Wilson's men could have been forgiven for throwing in the towel but instead they pulled one back less than ten minutes later.
Kieran MacDonald's cross was laid off by substitute Adam Brown and Ryan thumped high past the helpless Belford.
Within a couple of minutes, the Blues almost renewed their two-goal lead.
There seemed little on for Malcolm with his back to goal but he somehow found just enough to space curl a shot off the outside of the post with Ferguson and the Airdrie defence rooted to the spot.
It was becoming increasingly Airdrie though, with the Diamonds throwing everything at a resolute Stranraer defence.
Their best chance came 60 seconds from full time when the defence was caught out and the ball found Iain Russell.
The ex-Livingston man could only put his first time effort the wrong side of the post and Stranraer, deservedly, held on.
It is not a result which guarantees League One football for next season but it is another victory which keeps the Blues heading in the right direction.
Stranraer: Belford, Robertson, Dick, Neill, Pettigrew, Barron, Malcolm, Agnew, Turner, Gibson (Wilson 83), McGuigan (Kassarate 74).
Not used: Morena, Donald, Kemp and Currie.
Airdrieonians: Ferguson, Stewart, MacDonald, McIntosh, Mensing, Gorman (Brown 61), Hutton, Conroy, Ryan, Leitch (McKay 73), Russell.
Not used: Boateng, Cairns, Leighton, Loudon and Kerr.
Referee: Stephen Finnie